3 potential X-factors for the Buffalo Bills defense vs. Miami Dolphins in Week 3

The Buffalo Bills play their second consecutive AFC East foe Thursday night, squaring off against the Miami Dolphins. Buffalo (2-0) looks to add to Miami's (0-2) early-season misery.

The Bills have had the best of the recent matchups, winning six consecutive games against the Dolphins. Going a bit further back, Buffalo's has had a stranglehold in this series, winning 14 of the previous 16 matchups.

Which Bills have the potential to play a massive role in continuing the team's dominance? Here are three X-factors for Buffalo's defence ahead of Thursday's game.

Joey Bosa

Sep 14, 2025; East Rutherford, New Jersey, USA; Buffalo Bills defensive end Joey Bosa (97) causes a fumble on New York Jets quarterback Justin Fields (7) during the first half at MetLife Stadium. Mandatory Credit: Robert Deutsch-Imagn Images

Miami's offensive line is in shambles. Miami has multiple linemen on injured reserve. The team tried to fill some gaps, only to see major struggles in Week 2 against New England. The unit received six penalty calls on the afternoon. It figures to be even more challening on the road this week.

Bosa has been stellar thus far for the Bills. His numbers are astounding, registering four tackles and one sack. However, he has forced three fumbles, and Bosa's pressure rate is strong. He is fifth among edge rushers with seven hurries, per Pro Football Focus.

This could be a primetime game where Bosa dominates.

Terrel Bernard

EAST RUTHERFORD, NEW JERSEY - SEPTEMBER 11: Running back Breece Hall #20 of the New York Jets rushes the football against Micah Hyde #23 and Terrel Bernard #43 of the Buffalo Bills during the third quarter of the NFL game at MetLife Stadium on September 11, 2023 in East Rutherford, New Jersey. (Photo by Elsa/Getty Images)

Bernard may take on a larger role this week with the possibility of Matt Milano being sidelined for this Thursday's game.

Devon Achane may be Miami's best option to get anything positive for the Dolphins defense. Bernard will need to fill running holes to prevent the speedy Achance from breaking loose. In addition, Achane is a receiving threat, so Bernard may be called upon to limit Achane's progress out of the backfield.

Christian Benford

MIAMI GARDENS, FLORIDA - JANUARY 07: Christian Benford #47 of the Buffalo Bills breaks up a pass to Cedrick Wilson Jr. #11 of the Miami Dolphins during the third quarter at Hard Rock Stadium on January 07, 2024 in Miami Gardens, Florida. (Photo by Megan Briggs/Getty Images)

Miami has two very good receivers in Tyreek Hill and Jaylen Waddle. Even though the Dolphins line has largely struggled to protect Tua Tagovailoa and provide him time to throw, the duo is still dangerous enough to put pressure on defenses.

Benford will work to lock down the duo. It's anticipated that he will see snaps against both players. As the game progresses, expect him to trail whichever Dolphins receiver becomes a greater threat throughout the game. If Benford can shut down his receiver, expect the Bills to force Miami into many punting situations.

This article originally appeared on Bills Wire: 3 potential X-factors for the Bills defense vs. Dolphins in Week 3

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